Jarro-Dophilus + Inulin-FOS- Essential Partners for Intestinal Health & Immunity

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• 6 synergistic species maximize health benefits

• Contains documented strain Bifidobacterium longum (Morinaga strain) BB536

• In capsule or powder forms

• 3.4 billion probiotic organisms guaranteed

• High potency

JARRO-DOPHILUS

The human gastrointestinal tract contains a large and diverse population of microorganisms — over 400 different bacterial species, most of which are anaerobic, i.e., thriving in non- or low-oxygen environments. These flora increase in numbers and complexity along the length of the gastrointestinal (GI) tract; the further down the stomach, the greater the number of bacteria. The composition of the intestinal microflora also varies from one individual to another depending on diet, age, medication (antibiotics), stress levels and physiological conditions. Some species or strains (subspecies) of friendly flora “implant,” that is, adhere to the intestinal and vaginal mucosa, while others are transient. Transient flora may reproduce while moving through the large intestines, but do not colonize and soon pass out in the stool.

Jarro-Dophilus™ is a superior probiotic formulation, providing billions of the two most important groups of probiotic bacteria, Lactobacilli and Bifidobacteria

The natural balance maintained within the intestines can become disrupted. In such cases, consuming sufficient probiotic bacteria via fermented foods or dietary supplements is essential to encouraging intestinal health. Indeed, the term probiotics is defined as a live microbial supplement that beneficially affects the host by improving its microbial balance. In other words, probiotics like Jarro- Dophilus provide benefits by improving the health of the host by positively affecting the intestinal tract.

Jarro-Dophilus utilizes synergistic groups of species that benefit each other. Mixed strain formulas are more economical and more convenient than singlespecies products. Research, however, has found that supplying multiple groups of lactic acid bacteria together facilitates their replication.

Suggested consumption ranges from 1 to 3 capsules per day, taken 20-60 minutes after eating. The important issues are 1) that the probiotic bacteria are available to the entire GI tract, and 2) that the strains be selected from the dominant Lactobacilli (abbr. as “L”) and Bifidobacteria (abbr. as “B”).

L. rhamnosus R0011 - (sometimes mistakenly called L. bifidus). This species has greater survivability than L. acidophilus. This strain was discovered and developed by the Institute of Immunobiology and Virology in Belgrade. It produces prodigious amounts of polysaccharides, which aid adherence and stimulate immunity.

L. plantarum - L. plantarum is a remarkable species. It survives aerobic (with oxygen) and anaerobic (without oxygen) conditions. It ferments 25 carbohydrates, survives high salt (10% solution), low stomach pH or bile acids better than any other lactobacillus species, and is capable of producing antioxidant activity! L. plantarum ferments grains, grasses and vegetables and is a normal part of the diet.

One capsule of Jarro-Dophilus contains approximately 3.4 billion organisms (12 billion per gram), supplying six different species: L. rhamnosus R0011, L. plantarum, L. casei, L. acidophilus R0052, B. breve and B. longum Morinaga strain BB536.

L. casei - L. casei is often used to make fermented milk products and cheeses. It is popular in Japan and has been the subject of research including minor immunological effects in the GI tract involving the inhibition of pathogens.

L. acidophilus R0052 - This proprietary culture of Institut Rosell is of human origin and was selected by because of its ability to ferment 15 carbohydrates into lactic acid rather than the 11 carbohydrates typical of this species. It is recommended to balance intestinal microflora thanks to its ability to exert antimicrobial actions against pathogens. Several clinical trials have demonstrated the beneficial effects of R0052 together with R0011 in supporting the digestive handling of milk sugar and in promoting normal regularity as well as activating healthy immune responses.

B. breve - B. breve is probably the most common species of bifidobacteria in infants, but it remains a lifelong resident throughout our lives. B. breve produces L+ lactic acid, ferments over 20 carbohydrates and shares other characteristics in common with B. adolescentis.

B. longum BB536 (morinaga strain) - Highly documented, with more than 30 years of research behind it, this strain from Japan implants, promotes bowel regularity, and antagonizes pathogens.

Combining Jarro-Dophilus™ with Inulin-FOS

Inulin-FOS is a pure natural extract of chicory. It provides many health benefits similar to soluble dietary fiber. Being a non-digestible carbohydrate, it is not broken down by the digestive tract and therefore does not raise blood glucose levels in the body. No fermentation of sugar is used during the extraction of Inulin-FOS, as it is a plant extract.

Each capsule of Jarro-Dophilus contains over 4 billion organisms at the time of manufacture, but Jarrow Formulas states 3.4 billion to ensure full potency, taking into account shipping, time and temperature.

Inulin-FOS is used by the beneficial bacteria residing in the colon as a food source, promoting the growth of beneficial bacteria, which suppress harmful organisms.

Jarro-Dophilus + Inulin-FOS is formulated with Institut Rosell’s own taxonomically defined strains from its culture collection developed over the past sixty years. The Institute is one of the most experienced producers of lactic acid-producing bacteria for food fermentation and probiotic supplementation in the world. They analyze and certify the type and potency of each organism contained in Jarro-Dophilus + Inulin-FOS before release. Jarro- Dophilus + Inulin-FOS , is the finest symbiotic (combining probiotics and prebiotics) product available.

Why Refrigeration is Required

Regular probiotics not produced with special technology to be stable die off rapidly at room temperature. At 70º F, the loss is at least 10 -15% per month. At over 80º F, loss is more rapid. Non-refrigeration for as much as a week will not produce significant loss of the 12 billion organisms per gram that Jarro-Dophilus contains at time of manufacture, but the product should be kept refrigerated.

Jarro-Dophilus™ + Inulin-FOS is the perfect combination for increasing your intestinal probiotic population and enhancing your health and well-being. Daily supplementation of probiotics will result in reduced production of putrefactive substances and toxic metabolites (such as ammonia, indole, skatol, cresol and phenols and amines). Inulin-FOS has been shown to enhance the growth of bifidobacteria and production of SCFAs (short chain fatty acids), while lowering intestinal PH, reducing transit time and slightly increasing fecal bulk.

Selected References

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8;70(3):213-20.
Easo JG, Measham JD, Munroe J, Green-Johnson JM. Immunostimulatory
actions of lactobacilli: Mitogenic induction of antibody production and
spleen cell proliferation by Lactobacillus delbrueckii subsp. bulgaricus
and Lactobacillus acidophilus. Food and Agricultural Immunology
2002;14:73-83.
Gopal PK, et al. In vitro adherence properties of Lactobacillus rhamnosus
DR20 and Bifidobacterium lactis DR10 strains and their antagonistic
activity against an enterotoxigenic Escherichia coli. Int J Food Microbiol.
2001 Aug 5;67(3):207-16
Grill JP, Cayuela C, Antoine JM, Schneider F. Effects of Lactobacillus
amylovorus and Bifidobacterium breve on cholesterol. Lett Appl Microbiol.
2000;31:154-156.
Kostrzynska M, Hawke A, Dixon J, and Lepp D. The effect of probiotic
microorganisms on the adhesion of E. coli O157:H7 to intestinal epithelial
cells. Presented at the 4th Food Network Meeting, Lacombe, AB Canada
on May 30 - 31, 2002.
Kruisselbrink A, et al. Recombinant Lactobacillus plantarum inhibits
house dust mite- specific T-cell responses. Clin Exp Immunol. 2001
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Isolauri E, Sutas Y, Kankaanpaa P, Arvilommi H, Salminen S. Probiotics:
effects on immunity. Am J Clin Nutr. 2001 Feb;73(2 Suppl):444S-450S.
Lievin-Le Moal V, et al. Lactobacillus acidophilus (strain LB) from the
resident adult human gastrointestinal microflora exerts activity against
brush border damage promoted by a diarrhoeagenic Escherichia coli in
human enterocyte-like cells. Gut. 2002 Jun;50(6):803-11.
Matsumoto S, Watanabe N, Imaoka A, Okabe Y. Preventive effects of
Bifidobacterium- and Lactobacillus-fermented milk on the development
of inflammatory bowel disease in senescence- accelerated mouse P1/Yit
strain mice. Digestion. 2001;64(2):92-9.
Naruszewicz M, Johansson ML, Zapolska-Downar D, Bukowska H.
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factors in smokers. Am J Clin Nutr. 2002 Dec;76(6):1249-55.
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Source: Jarrow Formulas