Colostrum Brochure- Colostrum SpecificT Colostrum Prime LifeT and Lactoferrin

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Colostrums

. From First Milk Only - Within the First 12 Hours

. Freeze Dried Only - Never Spray Dried

. Verified by the Presence of Antibodies, Transfer Factors and Nerve Growth Factors

Lactoferrin

. Promotes the Growth of Bifidobacterium

. Enhances Natural Killer Cell and Neutrophil Activity

. Colostrum and Lactoferrin Help Maintain Proper Low Yeast Levels in the Body

Supplements to Support the Immune System

Why Colostrum, the "First Milk", is So Important

Newborn babies have weak, underdeveloped immune responses. They must rely upon a gift from their mothers during their first weeks of life - colostrum, which is the special first milk - for protection against bacteria, viruses and fungi. Colostrum is a source of immunoglobulins, which supply passive immunity to newborns as a defense against infections. Considerable evidence points to immunoglobulins also being active against infectious diarrhea caused by enteric bacteria and against Candida albicans. In fact, colostrum is so important to newborn calves that, if they do not receive it, most of these calves will die within three months of birth.

Immunoglobulin Factors

These immunoglobulins (Ig) consist of structurally related proteins, also called gammaglobulins, all of which act as antibodies. These components of the immune system include IgA, IgE, IgG, etc., each of which is itself a "family" of more closely related proteins. In the newborn, immunoglobulins supply "passive immunity", meaning that the mother's immune response to pathogens, a response developed from her own exposure, is made available to the baby through the colostrum in her milk.

Colostrum provides at least two more benefits to the immune system: "transfer factor" and lactoferrin. Transfer factor (TF) refers to a form of RNA (ribonucleic acid) which "transfers" the coding for cell-mediated immunity, meaning the immunity which depends upon Tcells (T-lymphocytes), as opposed to the immunity based on the B-cells, which produce antibodies. Whereas the B-cells are very short-lived, the T (thymus-derived) immune cells are involved in immune reactions which can continue for months or even years. Colostrum stimulates cell-mediated immunity.

The Issue of Processing

Jarrow FORMULAS® Colostrum is collected from healthy cows grazed on pasturage (except in winter). Herds grazed on pasturage are exposed to a variety of organisms and thereby develop a more comprehensive immune response.

Immunoglobulins themselves are quite fragile and therefore need proper handling and processing. Two factors involving this collection and processing of colostrum determine the value of colostrum supplements. First, true colostrum can only be collected within 12 hours of calving for maximum activity. Second, only freeze-drying ensures that the different colostrum immunoglobulin fractions and growth factors retain their biological activity and are not denatured. Many manufacturers utilize spray drying, but spray drying substantially denatures colostrum. Jarrow FORMULAS® colostrum products are freeze-dried, being frozen and dehydrated in a vacuum without heat.

Colostrum Prime LifeT and Colostrum SpecificT adhere to these standards, producing two very beneficial dietary supplements. Moreover, both products are tested for immunoglobulin levels, nerve growth factor and transfer factor after collection to ensure that every bottle is genuine colostrum.

Colostrum SpecificT

Colostrum SpecificT is freeze-dried bovine colostrum in enteric-coated capsules for specific delivery to the intestines. The enteric coating prevents degradation as the colostrum passes through the stomach.

Lactoferrin, The Natural Bacteriocide Found in Colostrum

Lactoferrin, a component of colostrum, is an ironbinding protein which is activated by the inflammation response. It is found in milk, but also in the tears, saliva and mucosal secretions of mammals. Early investigators believed that lactoferrin acted primarily by binding iron (as do many antibiotics) and thus preventing pathogenic bacteria from dividing and multiplying. New research, however, demonstrates that lactoferrin actually does much more than merely deprive pathogenic bacteria of iron. Studies have shown that lactoferrin attacks the outer membrane of gram-negative bacteria. This attack disrupts the membrane and makes the bacterial cell less viable. There is some evidence that the adherence of lactoferrin to bacteria enhances recognition by immune cells. Lactoferrin, therefore, may make natural killer cells and other neutrophils more active.

An especially interesting discovery is that lactoferrin becomes much more active as a bactericidal after it has been digested by pepsin and acid proteases in the stomach. The peptide lactoferricin B is liberated from the larger lactoferrin molecule. Lactoferricin B, like lactoferrin, plays a role in supporting the immune system. In vitro tests confirm lactoferrin's extremely strong activity against both gram-negative and gram-positive bacteria, and Candida albicans. In other words, exposure to digestion in the stomach possibly increases the potency of lactoferrin via the liberation of lactoferricin B.

Lactoferrin has been shown to be active in both in vitro and in vivo tests against a large number of pathogens. Lactoferrin has a specific binding capacity for Escherichia coli (E. coli) bacteria such as are often found in human intestinal infections. In contrast to its negative impact upon pathogens, lactoferrin does not affect the probiotic bacteria (good bacteria) Lactobacillus, a beneficial bacteria; it actually may promote the growth of Bifidobacteria, which is found in the large intestine.

Only the Best

Jarrow FORMULAS® Colostrum products are collected from cows that are pasture-fed, except in the winter, are free of antibiotics and hormones, and are USDA certified for colostrum import.

Colostrum Prime Life contains a minimum of 35% immunoglobulins (IgGs), which is 1/3 higher than typical colostrum products. It is rich in lactoferrin, and freeze-dried to maintain potency and quality. 120 capsules of 500 mg each.

Colostrum Specific is freeze-dried colostrum. The enteric coated capsules protect the special colostrum proteins from digestion by the stomach. 60 capsules of 500 mg each. Lactoferrin is freeze-dried, low-iron glycoprotein from whey.

Lactoferrin benefits intestinal health by promoting the growth of lactobacilli and bifidobacteria. 60 capsules each containing 250 mg of lactoferrin.

Usage

Colostrum Prime Life and Colostrum Specific are usually supplemented at two to four capsules per day taken between meals. Lactoferrin is taken at the rate of one to two capsules per day with food.

Selected References

Bjorck, L., “Antibacterial effect of lactoperoxidase system on
psychotropic bacteria in milk,” Journal of Dairy Research 45 (1978)
109-118.
Bellamy, W., et. al. “Identification of the bactericidal domain of
lactoferrin,” Biochemica et Biophysica Acta 1121 (1992) 130-136.
Holt, S. “Colostrum as a dietary supplement,” Alternative &
Complementary Therapies 4, 4 (August 1998) 276-283.
Naidu, S., et. al. “Specific binding of lactoferrin to Escherichia coli
isolated from human intestinal infections,” APMIS 99 (1991)
1142-1150.
Percival, M. “Intestinal Health,” Clinical Nutrition Insights 5, 5
(1997) 1-6.
Playford, RJ, Macdonald, CE, and Johnson, WS. Colostrum
and milk-derived peptide growth factors for the treatment of
gastrointestinal disorders. Am J Clin Nutr 2000;72:5-14.
Saito, H., et. al. “Physiochemical and antibacterial properties of
lactoferrin and its hydrolysate produced by heat treatment at acidic
pH,” in Hutchens, T.W., et. al., Lactoferrin: Structure and Function
(New York: Plenum Press, 1994) 219-226.
Saito, H., et. al. “Potent bactericidal activity of bovine lactoferrin
hydrolysate produced by heat treatment at acidic pH,” Journal of
Dairy Science 74 (1991) 3724-3730.
Momita, M., et. al. “Potent antibacterial peptides generated by
pepsin digestion of bovine lactoferrin,” Journal of Dairy Science 74
(1991) 4137-4142.
Wharton, BA, Balmer, SE, and Scott, PH. “Faecal Flora in the
Newborn,” in Hutchens, T.W., et. al., Lactoferrin: Structure and
Function (New York: Plenum Press, 1994) 91-98.

Source: Jarrow Formulas