Bone-Up - With Hydroxyapatite from Australian Bovine Bone

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. The most complete nutritional regimen for bones

. Utilizes hydroxyapatite calcium, the same form found in the human body

. Includes the complementary set of vitamins and minerals for skeletal health

. The correct calcium-magnesium ratio for optimum nutrition

Jarrow FORMULAS® Bone-Up® is the most complete nutritional regimen for healthy bones. It starts with the finest source of calcium available: Australian bovine bone hydroxyapatite from chemical-free, range-grazed calves less than two years old. (Bones from veal calves are never used).

Hydroxyapatite (HA) is the same form of calcium found in human bone tissue. What's more, this is bovine bone that has not been ashed (heated to a high temperature) or subjected to any chemical solvents. Non-ashed bone meal has shown the ability to increase bone mass. High heat, on the other hand, increases the net calcium content, but the special proteins and other beneficial compounds are burned off.

Skeletal health, however, requires more than calcium alone. It also requires magnesium, zinc, manganese, copper, vitamin C, vitamin D3, vitamin K, folic acid, boron, and glucosamine (all of which are beneficial for optimizing skeletal health). That's why all of these nutrients are included in the Bone-Up® formulation, and it's why we can say with confidence that Bone-Up® is indeed the most healthful regimen for bones.

Bone Mass and Hydroxyapatite

In 1982, an important calcium supplementation study was concluded and reported by the Dept. of Medicine and Radiology, Royal Free Hospital in London, England. Fiftythree post-menopausal women diagnosed to have seriously impaired calcium absorption and accelerated bone loss had been separated into three groups and studied for over 14 months. All participants had their forearm bones measured by x-ray radiogrammetry at the start of the study, and everyone received intramuscular injections of 100,000 units of vitamin D2 each month.

The control group received nothing more. The second group received 4 tablets (approximately 1,000 mg) per day of organic calcium (as gluconate). The third group received 8 tablets of hydroxyapatite, (approximately 1,000 mg) of calcium per day. [Note: The dosage of vitamin D used in this study should only be administered under the direct supervision of your medical practitioner].

At the end of the 14 month period, follow-up measurements of the forearm bones showed significant differences: the control group (vitamin D only) showed "significant loss of cortical bone." The calcium gluconate and vitamin D group showed virtually "no change" in bone status. The hydroxyapatite and vitamin D group showed "a significant increase in bone thickness."

Hydroxyapatite produces more prolonged calcium balance than soluble calcium salts. It also allows the bone osteoblast cells to be more receptive to its components and to build bone tissue. Furthermore, HA provides both the organic and inorganic constituents found in human bone: Hydroxyapatite microcrystals consists of calcium, phosphorous, oxygen, and hydrogen; the trace minerals zinc, strontium, silicon and iron; and proteins, amino acids and aminoglycans.

Bones and Osteoporosis

Bone consists of calcium and phosphorous crystals embedded in a framework of interlocking protein fibers. The protein fibers are made primarily of collagen. The mineral crystals give bone hardness, strength, and rigidity. Collagen fibers impart their quality of flexibility. Hydroxyapatite composes 67% of the weight of bone, and the collagenous fibers make up the remaining 33%.

The average adult has 1,000 -1,200 grams of calcium in the body. Bones are the body's largest calcium storehouse and will release calcium into the bloodstream in order to ensure correct blood levels of calcium. Thus, blood calcium levels can be normal while bone loss can be considerable, and this mechanism is one of the major causes of osteoporosis.

Between 2 - 4% of a person's skeleton is remodeled every year. This means that calcium and other minerals leave the bone in a process called resorption and then must be "remodeled" or replaced. Whether due to poor nutrition or reduced hormone levels with the onset of aging, the loss of calcium and other minerals from the bone creates tiny holes that make bones weak and brittle, particularly if collagen is being lost. This is how osteoporosis develops.

25%-30% of white and Asian women and perhaps 20% of black women develop osteoporosis. According to the FDA, the cause of osteoporosis in black women is more often due to calcium-poor diets or diets high in calcium antagonists rather than the lower rate of estrogen production from menopause.

More than one million fractures occur annually in women 45 years or older. 70% are sustained by women with osteoporosis. 33% of women and 17% of men have hip fractures by age 90. Men have one-quarter the rate of osteoporosis as do women. (FDA Consumer July-Aug. 1995, 21) Hip fractures carry a mortality rate of 12-15% and are the second leading cause of death in people 47-74 years of age. Of the 190,000 hip fractures per year, twothirds are due to osteoporosis. Osteoporosis costs close to $5 billion annually, not including lost work. Fractures result in diminished quality of life, and half of these patients who survive can no longer live independently and must enter a nursing home. (Hip fractures occur when the bones become so weak that they can no longer support the person's weight. The bone fractures and then the person falls).

Post-menopausal women lose 0.7% to 2% of their bone per year; men lose 0.5%-0.7%. Between 45 and 75 years of age, women lose 30% of their skeletal structure and men lose 15%.

Calcium supplementation of 1-1.5 grams (1,000-1,500 mg) per day can reduce fracture rates by 50%. Physician supervised estrogen therapy for women can reduce fractures by another 25% (Am Family Physician, 32:107-114, Nov. 1985).

The Truth About the 2:1 Calcium-to- Magnesium Ratio

Calcium supplements are available in many forms, but only hydroxyapatite as found in Bone-Up® provides a calcium source closest to human bone. Some products add magnesium or zinc and make a mineral trio. But, bones simply require more than one, two, or three nutrients.

Some formulas feature a reverse ratio of half as much calcium as magnesium (1:2). Established human nutrition requires approximately twice the calcium as magnesium (2:1). Though certain conditions (such as premenstrual syndrome) might benefit temporarily from higher amounts of magnesium, it has long been known that taking more magnesium than calcium can actually suppress calcium levels and increase bone loss by decreasing production of the thyroid hormone calcitonin. Magnesium intake must not be excessive or it acts as an undesirable calcium blocker.

A proper bone maintenance formula must contain more calcium than magnesium plus a full range of minerals and vitamins requisite to skeletal health. Bone-Up® contains these and also is formulated with MK-7 (an advanced form of Vitamin K2), Methylcobalamin (Methyl B12), and Glucosamine to provide additional benefits.

Who Needs to Supplement Calcium

85% of women over the age of 20 and at least 50% of men from age 35 consume less than the RDI for calcium. People who eat little or no dairy have difficulty obtaining enough calcium. Caffeine, alcohol, sugar, chocolate, and soda pops - particularly colas that are high in phosphorous - deplete calcium. High protein diets contribute large amounts of sulfur and phosphorous which lessen the alkalinity of the bloodstream. In order to maintain proper alkaline pH, parathyroid hormone stimulates the release - and depletion - of calcium from bone and teeth tissue. Therefore, high protein diets require increased calcium intake.

While children may absorb as much as 75% of ingested calcium, adults absorb about 30%. Calcium absorption has long been thought to be stomach-acid dependent, but both stomach acid production and calcium absorption decline with age! Also with age, people consume less calories, and hence, less calcium - compounding the problem because older people need to increase their calcium intake. In women, calcium absorption is particularly affected by menopause and the loss of a significant portion of estrogen production. Estrogen is crucial for maintaining their calcium status.

Usage

Mineral supplements are best taken with each meal in divided units because smaller amounts taken throughout the day yield a higher percentage of absorption. Take 1 to 6 Bone-Up® capsules per day, or as directed by your qualified health consultant.

References

Am J Clin Nutr, Sep. 1982, 36:426-430.
Morgan KJ, Magnesium and Calcium Dietary Intakes of the U.S. Population, I Am
CoIl Nutr, 1985, 4:195-206.
McDennott and Kies. “Nutritional Bioavailability of Manganese” in Nutritional
Bioavailability of Manganese. Constance Kies, editor. 1987. American Chemical
Society.
Am J Clin Nutr, 1982, 35:1048-1075.
U Nutr, 1981, 111:68-75; Am J Clin Nutr, 1982, 35; Pediatric Research, 1980, 14:
876-880.
Strause and Saltman. Role of Manganese in Bone Metabolism. Nutritional
Bioavailability of Manganese. Constance Kies, editor. 1987. American Chemical
Society.
Eaton-Evans J et al., Proc Nutr Soc, 1995, 54:19 lA.
Nielsen FH. Studies on the Relationship between Boron and Magnesium Which
Possibly Affects the Formation and Maintenance of Bones. Magnesium Trace Elem.
1990;9(2):61-9.
Nielsen FH, Hunt CD, Mullen LM, Hunt JR. Effect of dietary boron on mineral,
estrogen, and testosterone metabolism in postmenopausal women. FASEB Journal.
1987 Nov;1(5):394-7.
Principles of Anatomy and Physiology, Tortorra and Anagnostakos.
Gaby, AR, MD and Wright, JV, MD, Nutrients and Bone Health, Wright/Gaby Nutrition
Institute, 1988.
FDA Consumer. July-Aug. 1995, 21.
Am Family Physician, 32:107-114, Nov. 1985.
Care, A.D. et al., The Effects of Hypermagnesaemia on Calcitonin
Secretion In Vivo. Journal of Endocrinology, 1971; 51: 381-386
Iseri LT, et al., Magnesium: Nature’s Physiologic Calcium Blocker,
Am Heart J, 1985; 108: 188-193
Wall Street Journal, 1-20-86, II

Source: Jarrow Formulas